Interleukin 33 expression in human arthritis
نویسندگان
چکیده
منابع مشابه
Interleukin-33 in human gliomas: Expression and prognostic significance
Interleukin-33 (IL-33) is a nuclear and pleiotropic cytokine with regard to its cellular sources and its actions. IL-33 is involved in the pathogenesis of brain diseases. Several factors account for the tumorigenicity of human gliomas, including cytokines and their receptors. The present study assessed the expression and prognostic significance of IL-33 in human astroglial brain tumors. Protein...
متن کاملMeasurement of Interleukin-33 (IL-33) and IL-33 Receptors (sST2 and ST2L) in Patients with Rheumatoid Arthritis
The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the...
متن کاملLevels of Interleukin 33 and Interleukin 27 in Rheumatoid Arthritis and Osteoarthritis Egyptian patients
Background: Cytokines are important mediators of immune functions in humans and animals. IL-27, an IL-12 family cytokine, exerts a critical role in immune regulation in the context of infection and autoimmunity. IL-33, a newly foundIL-1 family cytokine is involved in joint inflammation in rheumatoid arthritis (RA). So, we aimed to investigate the immunopathological roles of IL-27 and IL-33 in s...
متن کاملNuclear expression of interleukin-33 in pancreatic stellate cells.
Activated pancreatic stellate cells (PSCs) play a pivotal role in pancreatic fibrosis in chronic pancreatitis and pancreatic cancer. Recent studies have suggested a role of IL-33, a newly identified IL-1 family member, in fibrosis. We here examined the expression of IL-33 and the IL-33-mediated regulation of cell functions in PSCs. PSCs were isolated from human and rat pancreas tissues. The exp...
متن کاملInterleukin-33 induces interleukin-8 expression via JNK/c-Jun/AP-1 pathway in human umbilical vein endothelial cells
Interleukin (IL)-33 is a member of the IL-1 cytokine family with dual functions as a traditional cytokine and as a transcriptional regulator. We recently reported that IL-33 up-regulated growth regulated oncogene (GRO)-α/CXCL1 expression in human vascular endothelial cells. The aim of this study was to investigate the effect of IL-33 on the expression of IL-8/CXCL8, another member of the CXC-ch...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2011
ISSN: 0003-4967
DOI: 10.1136/ard.2010.148965.4